For the problem of cracking defect for large diameter titanium alloy rivets in the spin riveting process, the simulation model of the spin riveting process was established by the finite element software ABAQUS，and the finite element model was simulated and calculated by the Explicit solver. Through the research and analysis on the simulation results and the spin riveting deformation process, the process parameters of the spin riveting were optimized (the reduction per pass reached 1.5 mm), and the local structure (the excircle fillet of rivet head was R1 mm) and size (the length of rivet exceeding the surface of part reduced from 10 mm to 6 mm) of rivet were improved. Then, the optimized spin riveting process was verified by the finite element method again. The results show that the stress of titanium alloy rivets in the spin riveting process is 859 MPa, which is lower than the material tensile strenght of 921.97 MPa. Finally, it proves that the improved process scheme can effectively solve the cracking defect of large diameter titanium alloy rivet in the spin riveting process by experiment verification, and it achieves the purpose of guiding the design and production.