For spring steel C75S with high strength, the blanking process of sheet metal was simulated by Deform-2D, and the process parameters were optimized based on response surface method. Then, a blanking experiment was conducted by central composite design, and the response surface model was established based on the values between process parameters and maximum die wear depth. Furthermore, it was found that the sequences of interactive influence of blanking process parameters on die wear depth were fillet of dies and blanking speed, fillet of dies and blanking clearances, blanking speed and blanking clearances. Thus, the best process was obtained by software of Design Expert with the fillet of dies 1.84t, the blanking speed 7.60 mm·s-1, the blanking clearance 13.23%t, and the wear depth of punch 4.02×10-6 mm. In addition, the blanking experiment was carried out, and the die wear was verified by height of blanking burr indirectly. The error between experimental value and optimal value by response surface method was 14.19%, and the experimental value was in good agreement with the optimal value. Therefore, it provided an effective method to optimize the die wear of blanking for sheet metal.