The self-piercing riveted joints were prepared by using advanced high-strength steels of HC340/590DP and HC420/780DP and AlSi10MnMg-T7 cast aluminum as the raw material combination, and the influences of thickness for different types of steel and aluminum plates on the forming quality and mechanical properties of self-piercing riveted joints were studied. The results show that the peak failure load in the combined joint with the lower aluminum plate thickness of 3.0 mm decreases with the increasing of the upper steel plate thickness, the minimum peak forces of shear and cross tensile specimens are greater than 7.0 kN and 2.5 kN,respectively. The mechanical properties of the combined joint with the lower aluminum plate thickness of 6.0 mm are relatively stable, the peak forces of shear and cross tensile are greater than 13 kN and 6.0 kN,respectively.  When the upper steel plate thickness in the combined joint is 1.2 mm, the energy absorption performance of joint is outstanding, and the energy absorption level shows a downward trend as the plate thickness increases. When  the lower steel plate thickness in the combined joint is 3 mm, the failure mode of joint is mainly the detachment of rivet with the upper two layers of plate as a whole, while when the lower aluminum plate thickness is 6.0 mm, the failure mode of joint is mainly the fracture of rivet body.