Aimed at the problems of high forming difficulty, low forming accuracy and poor product consistency of C22 Hastelloy tube during its actual manufacture, the hydroforming process was adopted to replace the tailor-welding process, and the integral forming of special-shaped tube was realized. Then, the finite element model of tube hydroforming was constructed with the bent tube as the blank, and the lateral feeding amount affected the change rate of tube wall thickness was optimized to obtain the optimal lateral feeding amount by finite element analysis and test verification. Furthermore, the thinning and wrinkling of tube wall in the forming area were compared, and the appropriate hydraulic pressure was achieved by the simulation and result comparison test. The results show that the optimization of hydraulic pressure and lateral feeding amount can significantly improve the formability of tube. Thus, the hydraulic pressure and the lateral feeding amount determined by the finite element simulation are applied to the actual production to obtain the tube that meet the technical requirements.