In order to improve the mechanical properties of BT22 titanium alloy plate used as sensor substrate, BT22 titanium alloy plate was first treated by solid solution treatment at 850 ℃+0.5 h and then strengthened by cold rolling, and the influences of cold rolling deformation amount on the microstructure and tensile properties of solid solution BT22 titanium alloy plate were studied by experimental testing method. The results show that the comprehensive use of high cold rolling deformation amount and low recrystallization temperature can help BT22 titanium alloy plate to form more fine-sized grains when the recrystallization occurs. After rolling, the strength of BT22 titanium alloy plate is greatly improved compared with that before rolling, and the strength is increased by at least 200 MPa. With the increasing of cold rolling deformation amount, the strength of alloy increases continuously, but the increase amplitude decreases. Although the elongation of alloy decreases after cold rolling, it still remains above 10%. In addition, the maximum yield strength of alloy after cold rolling is obtained when the cold rolling deformation amount is 80%, and the yield strength, tensile strength and elongation of alloy are 1012 MPa, 1042 MPa and 10%, respectively.